Role of Vitamin D Receptor Gene Polymorphism with Steroid Receptors in Breast Cancer: an Update

This review touches on new insights into the possible role of Vitamin D receptors genetic polymorphisms, and steroid in patients diagnosed with breast cancer. is most common cancer women; further, it creates diverse illnesses among diseased patients, prognosis linked different subtypes present hormone receptors. Most studies focus epidemiology disease. However, fewer are done genes polymorphism prognosis, which plays a more significant diagnosis cancer, so by proper screening at level as early, can predict disease females will help clinicians better management Hence burden its ill effects be reduced patient care system. Thus levels serum vitamin (VDR) transcriptionally controls target cell proliferation, differentiation, death pathways ligand-dependent manner, providing protection against growth progression. Also, there strong relationships between VDR polymorphisms (estrogen, progesterone, androgen) receptors, We recommend early these using advanced molecular biology techniques like Real-time Polymerase chain reaction, Chemiluminescence, Western blotting to detect genotyping earlier stages non-invasive, patient-friendly, reliable, accurate. receptor gene themselves act predictive biomarkers for many that warranted further ethnic populations large sample sizes.